Quantitative Analysis of Vitamins

Vitamins are a kind of organic substances that humans and animals must obtain from food in order to maintain normal physiological functions, and play an important role in the process of human growth, metabolism and development. The vitamin nerve body neither participates in the formation of human cells nor provides energy for the human body. According to their chemical structure and water solubility vitamins are divided into two categories: water-soluble vitamins and fat-soluble vitamins.

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Sample Requirements

• Solid 2g
• Cells ≥ 10⁶
• Liquid 500μl
• Recommended to repeat more than 6 times

• Sample type: animal and plant tissue, cell, blood, etc.

• Liquid/solid samples, dry ice shipping; large pieces need to be cut into 1cm pieces

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Case Analysis

Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence Among American Young Adults: A 30-Year Follow-up Study

Journal: Diabetes Care       Impact factor: 16.019 Published date: July, 2020       Published by: Texas State University

Research Background

To prospectively examine intakes of folate, vitamin B6, and vitamin B12 in relation to diabetes incidence

Research Design and Methods

A total of 4,704 American adults aged 18–30 years and without diabetes were enrolled in 1985–1986 and monitored until 2015–2016 in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Dietary assessment was conducted by a validated dietary-history questionnaire at baseline, in 1992–1993, and in 2005–2006. The cumulative average intakes of folate, vitamin B6, and vitamin B12 were used in the analyses. Incident diabetes was ascertained by plasma glucose levels, oral glucose tolerance tests, hemoglobin A1c concentrations, and/or antidiabetic medications.

Research Result

During 30 years of follow-up, 655 incident cases of diabetes occurred.Intake of folate was inversely associated with diabetes incidence after adjustment for potential confounders. Higher folate intake was also associated with lower plasma homocysteine and insulin.

Figure 1 Research of Multivariate-adjusted HRs of diabetes incidence among quintiles of B vitamin intake

Figure 2 Research of multivariate adjusted HRs (95% ci) between folate intake levels and incidence of diabetes stratified by pre-determined factors: the CARDIA

Conclusion

Intake of folate in young adulthood was inversely associated with diabetes incidence in midlife among Americans. The observed association may be partially explained by mechanisms related to homocysteine level, insulin sensitivity, and systemic inflammation.

Reference

Jiang Nan,Gutierrez-Diaz Aimer,Mukundi Eric et al. Synergy between the anthocyanin and RDR6/SGS3/DCL4 siRNA pathways expose hidden features of Arabidopsis carbon metabolism.[J] .Nat Commun, 2020, 11: 2456