Animal Metabolomics

Animal Metabolomics

Food Quality Research

Medical Metabolomics

Plant Metabolomics

Solution for Animal Metabolomics

Application Fields

Animal science

Comparison of different traits between different varieties and strains; production performance evaluation; improvement of meat quality; quality evaluation of milk.

Agricultural insects and pest control

Metabolomics is combined with agricultural pest research to conduct research on insect resistance, growth and development, behavior, and molecular mechanisms.


The application of metabolomics in aquaculture is helpful for the study of fish disease prevention, immunity, growth and development, nutrition, and combined with multi-omics to study the relevant molecular mechanisms.

Animal medical model

Most studies of human diseases have used mice as medical models, but they do not exhibit the same characteristics as humans for certain diseases. It is of great significance to search for appropriate animal medical models for the study of human diseases. At present, a variety of agricultural animals have been used in the study of human diseases.

Metabolomics Technology

Untargeted Metabolomics

Qualitative and quantitative analysis of all small molecule metabolites in a biological system is an unbiased metabolomics analysis method.

Global Untargeted Metabolomics

Compared with ordinary untargeted metabolomics, the second generation of untargeted metabolomics has achieved a great improvement in the accuracy of detecting substance content.


Compare the changes of lipid metabolism network in different physiological states, and then identify the key lipid biomarkers in metabolic regulation. Finally reveal the mechanism of lipids in life activities.

Targeted Metabolomics

Quantitative analysis of fatty acids, short-chain fatty acids, bile acids, neurotransmitters, amino acids, organic acids, TMAO and related metabolites.

Animal Science Case Analysis

Metabolite Exchange between Mammalian Organs Quantified in Pigs

Journal: Cell Metabolism       Impact factor: 22.415 Published date: 2019       Published by: Princeton University, the United States

Research Background

Mammalian organs continuously exchange metabolites through circulation, but systematic-level studies on the mechanisms of metabolite exchange are lacking.

Research Method

In this paper, we compared the concentrations of metabolites in arterial blood and venous blood of 11 organs of fasting pigs by LC-MS technology.

Research Result

1) More than 90% of metabolites show arteriovenous differences in at least one organ; 2) The liver and kidney release not only glucose but also amino acids, which are mainly consumed by the gut and pancreas; 3) The liver preferentially consumes unsaturated fatty acids, while the kidneys consume circulating citrate and net oxidized lactate pyruvate, thereby contributing to circulating redox homeostasis; 4) Production or consumption of more than 700 tissue-specific metabolites was detected.


Jang Cholsoon,Hui Sheng,Zeng Xianfeng et al. Metabolite Exchange between Mammalian Organs Quantified in Pigs.[J] .Cell Metab., 2019, 30: 594-606.e3

Agricultural Insect Case Analysis

Midgut Metabolomic Profiling of Fall Armyworm (Spodoptera Frugiperda) with Field-evolved Resistance to Cry1F Corn

Journal: Insect Biochemistry and Molecular Biology       Impact factor: 3.827 Published date: 2019       Published by: University of Tennessee, the United States

Research Background

Populations of the fall armyworm (Spodoptera frugiperda) have developed resistance to transgenic corn producing the Cry1F insecticidal protein from the bacterium Bacillus thuringiensis (Bt).

Research Method

We hypothesized that Cry1F-resistant fall armyworm with a non-functional SfABCC2 protein would display altered gut metabolome composition when compared to susceptible insects. Mass spectrometry and multivariate statistical analyses identified 126 unique metabolites from larval guts, of which 7 were found to display statistically significant altered levels between midguts from susceptible and Cry1F-resistant S.

Research Result

Among these 7 differentially present 36 metabolites, 6 were found to significantly accumulate (1.3 to 3.5-fold) in midguts from Cry1F-resistant larvae, including nucleosides, asparagine, and carbohydrates such as trehalose 6-phosphate and sedoheptulose 1/7-phosphate. In contrast, metabolomic comparisons of larvae fed on non-transgenic corn identified 5 metabolites with statistically significant altered levels and only 2 of them, 2-isopropylmalate and 3-phosphoserine, that significantly accumulated (2.3- and 3.5-fold, respectively) in midguts from Cry1F-resistant compared to susceptible larvae. These may have the potential to be used as resistance markers.

Figure 1 (PLSDA)Partial least squares discriminant analysis (PLSDA) of midgut metabolites in larvae of different strains of Spodoptera frugiperda

Figure 2 Heat map of relative levels of intestinal metabolites in Spodoptera frugiperda larvae fed a semi-pure diet


H. Abdelgaffar et al., Midgut metabolomic profiling of fall armyworm (Spodoptera frugiperda) with field-evolved resistance to Cry1F corn. Insect Biochem Mol Biol. 2019 Mar;106:1-9


Dye Residues in Aquaculture Products: Targeted and Metabolomics Mass Spectrometric Approaches to Track their Abuse

Journal: Food Chemistry       Impact factor: 6.306 Published date: 2019       Published by: French Angers Chemical Laboratory

Research Background

The aim of the study was to initiate an exhaustive strategy of control by implementing both targeted and non-targeted metabolomics approaches. A LC-MS/MS method including an oxidative step for most of dyes was developed and validated to target the analysis of 14 residues belonging to different families of dyes. The metabolomics approach objective was to compare fingerprints between farmed fish treated with malachite green and farmed fish treated with victoria pure blue bo. Analytical information on modifications in the metabolome of muscle, liver and plasma was exploited by HRMS following by multivariate statistics and revealed some direct or endogenous metabolites among relevant mass features contributing to the constructed models. These two approaches, either appropriate biomarkers either enlarged targeted dyes are explored concomitantly to help improving the strategy for tracking new illegal practices in aquaculture.

Figure 1 Experiment process

Figure 2 PLS-DA diagram


E. Dubreil et al.,Dye residues in aquaculture products: Targeted and metabolomics mass spectrometric approaches to track their abuse. Food Chemistry 294 (2019) 355–367

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