New Drug Development Stage

Pre-clinical research:

comprehensively analyze the relationship between pharmacological and toxicological research results at different stages and safety, effectiveness and quality controllability, so as to facilitate the steady and orderly development of new drugs and reduce the risk of drug development.

Pharmacodynamic evaluation
Pharmacokinetics
Guide the production process

Clinical research:

effectively predict and avoid adverse reactions of drugs, fully consider the characteristics of clinical diseases, drug pathways and mechanisms of action, adaptation to the population, etc., to better guide the clinical application of drugs.

Clinical efficacy evaluation
Clinical safety evaluation

Classic Case:

metabolome-based drug discovery and development ----Take TMAO in atherosclerotic applications as an example

01
Identify metabolites associated with the disease
02
Clinical validation and confirmation of biomarker
03
Targeted drug activity analysis, drug evaluation
04
Animal & cell experiments, found target
05
Lead optimization, preclinical trials and ADMET studies
06
Clinical trials